A sequel, following Michael Jackson’s life and career post-1988, is said to be in development following “Michael” becoming a smash hit.

- Jaafar Jackson as Michael Jackson
- Juliano Valdi as young Michael
- Colman Domingo as Joseph Jackson, Michael’s father
- Nia Long as Katherine Scruse-Jackson, Michael’s mother
- Miles Teller as John Branca, Michael’s attorney
- KeiLyn Durrel Jones as Bill Bray, Michael’s bodyguard
- Laura Harrier as Suzanne de Passe, creative assistant to Berry Gordy at Motown
- Joseph David-Jones as Jackie Jackson, Michael’s older brother
- Nathaniel Logan McIntyre as young Jackie
- Rhyan Hill as Tito Jackson, Michael’s older brother
- Judah Edwards as young Tito
- Jamal R. Henderson as Jermaine Jackson, Michael’s older brother
- Jayden Harville as young Jermaine
- Tre Horton as Marlon Jackson, Michael’s older brother
- Jaylen Lyndon Hunter as young Marlon
- Jessica Sula as La Toya Jackson, Michael’s older sister
- Mike Myers as Walter Yetnikoff, president of CBS Records
- Kendrick Sampson as Quincy Jones, a co-producer for three of Michael’s solo albums
- Larenz Tate as Berry Gordy, music producer and president of Motown
- Liv Symone as Gladys Knight, singer and actress
- Deon Cole as Don King, a boxing promoter
- Asia Fuqua as Ola Ray, Michael’s co-star in the “Thriller” music video
- Jono Petrie as John Landis, the director of the “Thriller” music video
- Paul Hipp as Bob Giraldi, the director of the “Beat It” music video and the 1984 Pepsi commercial